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Non-natural amino acids into LfcinB-derived peptides: effect in their (i) proteolytic degradation and (ii) cytotoxic activity against cancer cells

The dimeric peptide 26[F]: (RRWQWRFKKLG)2-K-Ahx has exhibited a potent cytotoxic effect against breast cancer cell lines, with position 26 (F) being the most relevant for anti-cancer activity. In this investigation, six analogues of the 26[F] peptide were synthesized in which the 26th position was r...

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Kaydedildi:
Asıl Yazarlar: Diego Sebastián Insuasty-Cepeda, Andrea Carolina Barragán-Cárdenas, Natalia Ardila-Chantre, Karen Johanna Cárdenas-Martínez, Isabella Rincón-Quiñones, Yerly Vargas-Casanova, Alejandra Ochoa-Zarzosa, Joel Edmundo Lopez-Meza, Claudia Marcela Parra-Giraldo, Luis Fernando Ospina-Giraldo, Ricardo Fierro-Medina, Javier Eduardo García-Castañeda, Zuly Jenny Rivera-Monroy
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Royal Society 2023-06-01
Seri Bilgileri:Royal Society Open Science
Konular:
non-natural amino acids
LfcinB-derived peptides
cytotoxic activity
MCF-7 cells
proteolytic degradation
Online Erişim:https://royalsocietypublishing.org/doi/10.1098/rsos.221493
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