Non-natural amino acids into LfcinB-derived peptides: effect in their (i) proteolytic degradation and (ii) cytotoxic activity against cancer cells

The dimeric peptide 26[F]: (RRWQWRFKKLG)2-K-Ahx has exhibited a potent cytotoxic effect against breast cancer cell lines, with position 26 (F) being the most relevant for anti-cancer activity. In this investigation, six analogues of the 26[F] peptide were synthesized in which the 26th position was r...

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Główni autorzy:	Diego Sebastián Insuasty-Cepeda, Andrea Carolina Barragán-Cárdenas, Natalia Ardila-Chantre, Karen Johanna Cárdenas-Martínez, Isabella Rincón-Quiñones, Yerly Vargas-Casanova, Alejandra Ochoa-Zarzosa, Joel Edmundo Lopez-Meza, Claudia Marcela Parra-Giraldo, Luis Fernando Ospina-Giraldo, Ricardo Fierro-Medina, Javier Eduardo García-Castañeda, Zuly Jenny Rivera-Monroy
Format:	Artigo
Język:	Inglês
Wydane:	The Royal Society 2023-06-01
Seria:	Royal Society Open Science
Hasła przedmiotowe:	non-natural amino acids LfcinB-derived peptides cytotoxic activity MCF-7 cells proteolytic degradation
Dostęp online:	https://royalsocietypublishing.org/doi/10.1098/rsos.221493
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