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Novel PEI/Poly-γ-Gutamic Acid Nanoparticles for High Efficient siRNA and Plasmid DNA Co-Delivery

The efficient delivery of sufficient amounts of nucleic acids into target cells is critical for successful gene therapy and gene knockdown. The DNA/siRNA co-delivery system has been considered a promising approach for cancer therapy to simultaneously express and inhibit tumor suppressor genes and ov...

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Autori principali: Shu-Fen Peng, Hung-Kun Hsu, Chun-Cheng Lin, Ya-Ming Cheng, Kuang-Hsing Hsu
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2017-01-01
Serie:Molecules
Soggetti:
polyethylenimine
poly-γ-glutamic acid
gene delivery
siRNA delivery
dual delivery nanoparticle
Accesso online:http://www.mdpi.com/1420-3049/22/1/86
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