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Guanidino compounds with native GABA(A) δ receptor selectivity: a tale of homeostatic compensation in δ-KO mice

Abstract Altered GABAergic transmission has been implicated in the neurological symptoms of metabolic disorders associated with guanidino compound (GC) accumulation. Building on previous findings that selected GCs act as direct orthosteric GABAA​ receptor (GABAR) agonists, we now asked whether these...

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Main Authors: Pratap Meera, Mikko Uusi-Oukari, Martin Wallner, Gerald S. Lipshutz
Format: Artigo
Language:Inglês
Published: BMC 2025-12-01
Series:BMC Neuroscience
Subjects:
GABAA receptor
GABA-mimetics
Extrasynaptic GABAA receptors
Guanidinoacetate
Guanidinopropionate
Online Access:https://doi.org/10.1186/s12868-025-00987-z
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