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Simultaneous detection of DNA variation and methylation at HLA class II locus and immune gene promoters using targeted SureSelect Methyl-Sequencing

The Human Leukocyte Antigen (HLA) locus associates with a variety of complex diseases, particularly autoimmune and inflammatory conditions. The HLA-DR15 haplotype, for example, confers the major risk for developing Multiple Sclerosis in Caucasians, pinpointing an important role in the etiology of th...

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Principais autores: Maria Kalomoiri, Chandana Rao Prakash, Sonja Lagström, Kai Hauschulz, Ewoud Ewing, Klementy Shchetynsky, Lara Kular, Maria Needhamsen, Maja Jagodic
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-08-01
coleção:Frontiers in Immunology
Assuntos:
HLA/MHC
DNA variance
DNA methylation
immune regulation
antigen presentation
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1251772/full
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