Simultaneous detection of DNA variation and methylation at HLA class II locus and immune gene promoters using targeted SureSelect Methyl-Sequencing

The Human Leukocyte Antigen (HLA) locus associates with a variety of complex diseases, particularly autoimmune and inflammatory conditions. The HLA-DR15 haplotype, for example, confers the major risk for developing Multiple Sclerosis in Caucasians, pinpointing an important role in the etiology of th...

Descrición completa

Detalles Bibliográficos

Principais autores:	Maria Kalomoiri, Chandana Rao Prakash, Sonja Lagström, Kai Hauschulz, Ewoud Ewing, Klementy Shchetynsky, Lara Kular, Maria Needhamsen, Maja Jagodic
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2023-08-01
Series:	Frontiers in Immunology
Assuntos:	HLA/MHC DNA variance DNA methylation immune regulation antigen presentation
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1251772/full
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!