Targeting tumor O‐glycosylation modulates cancer–immune‐cell crosstalk and enhances anti‐PD‐1 immunotherapy in head and neck cancer

Cells in the tumor microenvironment (TME) communicate via membrane‐bound and secreted proteins, which are mostly glycosylated. Altered glycomes of malignant tumors influence behaviors of stromal cells. In this study, we showed that the loss of core‐1 β1,3‐galactosyltransferase (C1GALT1)‐mediated O‐g...

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Autores principales:	Mei‐Chun Lin, Ya‐Ting Chuang, Hsin‐Yi Wu, Chia‐Lang Hsu, Neng‐Yu Lin, Min‐Chuan Huang, Pei‐Jen Lou
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Wiley 2024-02-01
Colección:	Molecular Oncology
Materias:	core 1 β1,3‐galactosyltransferase head and neck cancer IL‐6 immune checkpoint inhibitor itraconazole O‐glycosylation
Acceso en línea:	https://doi.org/10.1002/1878-0261.13489
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