Development of Glycosylation-Modified ^DPPA-1 Compounds as Innovative PD-1/PD-L1 Blockers: Design, Synthesis, and Biological Evaluation

In the context of peptide drug development, glycosylation plays a pivotal role. Accordingly, L-type peptides were synthesized predicated upon the PD-1/PD-L1 blocker ^DPPA-1. Subsequent glycosylation resulted in the production of two distinct glycopeptides, D-glu-^LPPA-1 and D-gal...

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Principais autores:	Peng Deng, Xiaodan Dong, Ziyuan Wu, Xixi Hou, Longfei Mao, Jingjing Guo, Wenshan Zhao, Chune Peng, Zhe Zhang, Lizeng Peng
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2024-04-01
Series:	Molecules
Assuntos:	cancer immunotherapy immune checkpoint PD-1/PD-L1 peptide glycosylation
Acceso en liña:	https://www.mdpi.com/1420-3049/29/8/1898
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