Modulation of lipid nanoparticle-formulated plasmid DNA drives innate immune activation promoting adaptive immunity

Summary: Nucleic acid vaccines have grown in importance over the past several years, with the development of new approaches remaining a focus. We describe a lipid nanoparticle-formulated DNA (DNA-LNP) formulation which induces robust innate and adaptive immunity with similar serological potency to m...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Nicholas J. Tursi, Sachchidanand Tiwari, Nicole Bedanova, Toshitha Kannan, Elizabeth Parzych, Nisreen Okba, Kevin Liaw, András Sárközy, Cory Livingston, Maria Ibanez Trullen, Ebony N. Gary, Máté Vadovics, Niklas Laenger, Jennifer Londregan, Mohammad Suhail Khan, Serena Omo-Lamai, Hiromi Muramatsu, Kerry Blatney, Casey Hojecki, Viviane Machado, Igor Maricic, Trevor R.F. Smith, Laurent M. Humeau, Ami Patel, Andrew Kossenkov, Jacob S. Brenner, David Allman, Florian Krammer, Norbert Pardi, David B. Weiner
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Elsevier 2025-04-01
Σειρά:	Cell Reports Medicine
Θέματα:	vaccine plasmid DNA lipid nanoparticle DNA-LNP mRNA adjuvanted protein
Διαθέσιμο Online:	http://www.sciencedirect.com/science/article/pii/S2666379125001089
Ετικέτες:	Προσθήκη ετικέτας Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!