Modulation of lipid nanoparticle-formulated plasmid DNA drives innate immune activation promoting adaptive immunity

Summary: Nucleic acid vaccines have grown in importance over the past several years, with the development of new approaches remaining a focus. We describe a lipid nanoparticle-formulated DNA (DNA-LNP) formulation which induces robust innate and adaptive immunity with similar serological potency to m...

Fuld beskrivelse

Bibliografiske detaljer

Principais autores:	Nicholas J. Tursi, Sachchidanand Tiwari, Nicole Bedanova, Toshitha Kannan, Elizabeth Parzych, Nisreen Okba, Kevin Liaw, András Sárközy, Cory Livingston, Maria Ibanez Trullen, Ebony N. Gary, Máté Vadovics, Niklas Laenger, Jennifer Londregan, Mohammad Suhail Khan, Serena Omo-Lamai, Hiromi Muramatsu, Kerry Blatney, Casey Hojecki, Viviane Machado, Igor Maricic, Trevor R.F. Smith, Laurent M. Humeau, Ami Patel, Andrew Kossenkov, Jacob S. Brenner, David Allman, Florian Krammer, Norbert Pardi, David B. Weiner
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2025-04-01
Serier:	Cell Reports Medicine
Fag:	vaccine plasmid DNA lipid nanoparticle DNA-LNP mRNA adjuvanted protein
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2666379125001089
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!