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PP242 Counteracts Glioblastoma Cell Proliferation, Migration, Invasiveness and Stemness Properties by Inhibiting mTORC2/AKT

Glioblastoma multiforme (GBM) is the most malignant brain tumor and is associated with poor prognosis due to its thorny localization, lack of efficacious therapies and complex biology. Among the numerous pathways driving GBM biology studied so far, PTEN/phosphatidylinositol-4,5-bisphosphate 3-kinase...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Carmen Mecca, Ileana Giambanco, Stefano Bruscoli, Oxana Bereshchenko, Bernard Fioretti, Carlo Riccardi, Rosario Donato, Cataldo Arcuri
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018-04-01
Schriftenreihe:Frontiers in Cellular Neuroscience
Schlagworte:
glioblastoma
mTOR
mTORC2
rapamycin
PP242
Online-Zugang:http://journal.frontiersin.org/article/10.3389/fncel.2018.00099/full
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