Plasma concentration of dexmedetomidine combined with fixed remifentanil for nociceptive and hemodynamic control during skull pin fixation

Abstract Skull pin fixation during neurosurgery induces intense nociceptive and hemodynamic responses. Dexmedetomidine is commonly used in anesthesia to enhance perioperative stability; however, its optimal plasma concentration (Cp) when combined with remifentanil at a fixed effect-site concentratio...

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Ngā kaituhi matua:	Wei-Cheng Tseng, Ann‑Shung Lieu, Yu-Chi Tu, Yu-Feng Su, Tsai-Shan Wu, Yi-Wei Kuo, Zhi-Fu Wu
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Nature Portfolio 2026-04-01
Rangatū:	Scientific Reports
Ngā marau:	Analgesia nociception index Dexmedetomidine Remifentanil Skull pin fixation Target-controlled infusion Total intravenous anesthesia
Urunga tuihono:	https://doi.org/10.1038/s41598-026-50692-y
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!