Plasma concentration of dexmedetomidine combined with fixed remifentanil for nociceptive and hemodynamic control during skull pin fixation

Abstract Skull pin fixation during neurosurgery induces intense nociceptive and hemodynamic responses. Dexmedetomidine is commonly used in anesthesia to enhance perioperative stability; however, its optimal plasma concentration (Cp) when combined with remifentanil at a fixed effect-site concentratio...

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Autors principals:	Wei-Cheng Tseng, Ann‑Shung Lieu, Yu-Chi Tu, Yu-Feng Su, Tsai-Shan Wu, Yi-Wei Kuo, Zhi-Fu Wu
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2026-04-01
Col·lecció:	Scientific Reports
Matèries:	Analgesia nociception index Dexmedetomidine Remifentanil Skull pin fixation Target-controlled infusion Total intravenous anesthesia
Accés en línia:	https://doi.org/10.1038/s41598-026-50692-y
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