The p53 tumor suppressor regulates AKR1B1 expression, a metastasis-promoting gene in breast cancer
Alteration of metabolism in cancer cells is a central aspect of the mechanisms that sustain aggressive traits. Aldo–keto reductase 1 B1 (AKR1B1) catalyzes the reduction of several aldehydes to alcohols consuming NADPH. Nevertheless, the ability of AKR1B1 to reduce different substrates renders diffic...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Frontiers Media S.A.
2023-09-01
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| Серии: | Frontiers in Molecular Biosciences |
| Предметы: | |
| Online-ссылка: | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1145279/full |
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