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Discontinuous EBOV RNA synthesis events in patients with Ebola virus disease and their relationship to viral load and outcome of infection

ABSTRACT Ebola virus (EBOV) is a negative strand RNA virus that causes Ebola virus disease (EVD) with a high case fatality rate. During the acute phase of infection, a subsequent fatal outcome is characterized by an increased upregulation of interferon and inflammatory pathways compared to survivors...

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Principais autores: Xiaofeng Dong, Isabel Garcia-Dorival, Natasha Y. Rickett, Andrew Bosworth, Sophie Smither, Stuart Dowall, Miles W. Carroll, David A. Matthews, Thomas R. Laws, Paul Digard, Julian A. Hiscox
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2025-12-01
Serier:Journal of Virology
Fag:
defective genomes
Ebola
viral replication
transcriptomics
Ebola virus
Online adgang:https://journals.asm.org/doi/10.1128/jvi.00826-25
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