PLXNC1 interference alleviates the inflammatory injury, apoptosis and extracellular matrix degradation of IL-1β-exposed chondrocytes via suppressing GRP78 expression

Abstract Background Osteoarthritis (OA) is a frequently encountered debilitating joint disorder. Whether plexin C1 (PLXNC1) is implicated in OA is far from being investigated despite its well-documented pro-inflammatory property in human diseases. The goal of this study is to expound the specific ro...

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Hauptverfasser:	Nan Meng, Lingwei Mao, Qinyi Jiang, Jishan Yuan, Linjuan Liu, Lei Wang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2023-10-01
Schriftenreihe:	Journal of Orthopaedic Surgery and Research
Schlagworte:	PLXNC1 GRP78 ECM degradation Chondrocytes OA
Online-Zugang:	https://doi.org/10.1186/s13018-023-04207-4
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