Inhibiting AMPA receptor signaling in oligodendrocytes rescues synapse loss in a model of autoimmune demyelination

Summary: Multiple sclerosis (MS) is initially characterized by myelin and axonal damage in central nervous system white matter lesions, but their causal role in synapse loss remains undefined. Gray matter atrophy is also present early in MS, making it unclear if synaptic alterations are driven by wh...

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Bibliografski detalji

Glavni autori:	Gabrielle M. Mey, Kirsten S. Evonuk, John Shelestak, Muhammad Irfan, Laura M. Wolfe, Sophia E. Laye, Dorothy P. Schafer, Tara M. DeSilva
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2024-11-01
Serija:	iScience
Teme:	Cell biology Immunology Neuroscience
Online pristup:	http://www.sciencedirect.com/science/article/pii/S2589004224024519
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