Inhibiting AMPA receptor signaling in oligodendrocytes rescues synapse loss in a model of autoimmune demyelination

Summary: Multiple sclerosis (MS) is initially characterized by myelin and axonal damage in central nervous system white matter lesions, but their causal role in synapse loss remains undefined. Gray matter atrophy is also present early in MS, making it unclear if synaptic alterations are driven by wh...

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Autori principali:	Gabrielle M. Mey, Kirsten S. Evonuk, John Shelestak, Muhammad Irfan, Laura M. Wolfe, Sophia E. Laye, Dorothy P. Schafer, Tara M. DeSilva
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2024-11-01
Serie:	iScience
Soggetti:	Cell biology Immunology Neuroscience
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2589004224024519
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