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Subcellular Compartmentalization of Glucose Mediated Insulin Secretion

Regulation of blood glucose levels depends on the property of beta cells to couple glucose sensing with insulin secretion. This is accomplished by the concentration-dependent flux of glucose through glycolysis and oxidative phosphorylation, generating ATP. The resulting rise in cytosolic ATP/ADP inh...

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Autori principali: Zhongying Wang, Tatyana Gurlo, Leslie S. Satin, Scott E. Fraser, Peter C. Butler
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2025-01-01
Serie:Cells
Soggetti:
compartmentalization
submembrane
beta cells
K<sub>ATP</sub> channel
mitochondria
oxidative phosphorylation
Accesso online:https://www.mdpi.com/2073-4409/14/3/198
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