Protein degradation technology: a strategic paradigm shift in drug discovery
Abstract Targeting pathogenic proteins with small-molecule inhibitors (SMIs) has become a widely used strategy for treating malignant tumors. However, most intracellular proteins have been proven to be undruggable due to a lack of active sites, leading to a significant challenge in the design and de...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2021-09-01
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| coleção: | Journal of Hematology & Oncology |
| Assuntos: | |
| Acesso em linha: | https://doi.org/10.1186/s13045-021-01146-7 |
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