Advancing cancer immunotherapy: Small-Molecule, biomacromolecular, and nanoscale PROTACs targeting PD-L1 for degradation
Programmed death-ligand 1 (PD-L1) is a key immune checkpoint protein that enables tumor immune evasion by engaging PD-1 on T cells, thereby inhibiting their cytotoxic function. Although immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis have marked a breakthrough in cancer therapy, th...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Elsevier
2025-08-01
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| Colección: | Materials Today Advances |
| Materias: | |
| Acceso en línea: | http://www.sciencedirect.com/science/article/pii/S2590049825000517 |
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