Sulfide, Sulfoxide, and Sulfone Derivatives of Usnic Acid as Inhibitors of Human TDP1 and TDP2 Enzymes

Tyrosyl-DNA phosphodiesterases 1 and 2 (TDP1 and TDP2) are important DNA repair enzymes that remove various adducts from the 3′- and 5′-ends of DNA, respectively. The suppression of the activity of these enzymes is considered as a promising adjuvant therapy for oncological diseases in combination wi...

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מידע ביבליוגרפי

Principais autores:	Aleksandr S. Filimonov, Marina A. Mikhailova, Nadezhda S. Dyrkheeva, Irina A. Chernyshova, Tatyana E. Kornienko, Konstantin A. Naumenko, Rashid O. Anarbaev, Andrey A. Nefedov, Chigozie Achara, Anthony D. M. Curtis, Olga A. Luzina, Konstantin P. Volcho, Nariman F. Salakhutdinov, Olga I. Lavrik, Jóhannes Reynisson
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	MDPI AG 2024-12-01
סדרה:	Chemistry
נושאים:	usnic acid sulfides sulfoxide sulfone tyrosyl-DNA phosphodiesterase TDP1 inhibitor
גישה מקוונת:	https://www.mdpi.com/2624-8549/6/6/101
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