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The Influence of TDP1 Inhibitor Usnic Acid Derivative OL9-116 on the Effects of Topotecan in Human Cells

Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a key enzyme for the repair of stalled topoi-somerase 1 (TOP1)-DNA complexes. We have previously developed a TDP1 inhibitor, compound OL9-116, which is capable of enhancing the action of the anticancer drug topotecan (TPC), a TOP1 poison, in vitro and in viv...

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Principais autores: Tatyana E. Kornienko, Arina A. Chepanova, Maria V. Kolobenko, Irina A. Chernyshova, Alexandra L. Zakharenko, Artur S. Venzel, Nadezhda S. Dyrkheeva, Andrey V. Markov, Rashid O. Anarbaev, Konstantin N. Naumenko, Olga A. Luzina, Nariman F. Salakhutdinov, Vladimir A. Ivanisenko, Olga I. Lavrik
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2026-04-01
coleção:Current Issues in Molecular Biology
Assuntos:
DNA repair
Tyrosyl-DNA phosphodiesterase 1 inhibitor
topotecan
TDP1 knockout
usnic acid derivative
Acesso em linha:https://www.mdpi.com/1467-3045/48/4/428
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