The Influence of TDP1 Inhibitor Usnic Acid Derivative OL9-116 on the Effects of Topotecan in Human Cells

Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a key enzyme for the repair of stalled topoi-somerase 1 (TOP1)-DNA complexes. We have previously developed a TDP1 inhibitor, compound OL9-116, which is capable of enhancing the action of the anticancer drug topotecan (TPC), a TOP1 poison, in vitro and in viv...

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Autors principals:	Tatyana E. Kornienko, Arina A. Chepanova, Maria V. Kolobenko, Irina A. Chernyshova, Alexandra L. Zakharenko, Artur S. Venzel, Nadezhda S. Dyrkheeva, Andrey V. Markov, Rashid O. Anarbaev, Konstantin N. Naumenko, Olga A. Luzina, Nariman F. Salakhutdinov, Vladimir A. Ivanisenko, Olga I. Lavrik
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2026-04-01
Col·lecció:	Current Issues in Molecular Biology
Matèries:	DNA repair Tyrosyl-DNA phosphodiesterase 1 inhibitor topotecan TDP1 knockout usnic acid derivative
Accés en línia:	https://www.mdpi.com/1467-3045/48/4/428
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