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Polyoxometalate inhibition of SOX2-mediated tamoxifen resistance in breast cancer

Abstract Background Increased cancer stem cell (CSC) content and SOX2 overexpression are common features in the development of resistance to therapy in hormone-dependent breast cancer, which remains an important clinical challenge. SOX2 has potential as biomarker of resistance to treatment and as th...

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Gardado en:
Principais autores: Iskander Aurrekoetxea-Rodriguez, So Young Lee, Miriam Rábano, Isabel Gris-Cárdenas, Virginia Gamboa-Aldecoa, Irantzu Gorroño, Isabella Ramella-Gal, Connor Parry, Robert M. Kypta, Beñat Artetxe, Juan M. Gutierrez-Zorrilla, Maria dM. Vivanco
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2024-09-01
Series:Cell Communication and Signaling
Assuntos:
Breast cancer
Cancer stem cells
Resistance
Hormone therapy
SOX2 inhibition
Polyoxometalate
Acceso en liña:https://doi.org/10.1186/s12964-024-01800-w
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