High molecular weight insoluble parkin in the substantia nigra of patients with idiopathic Parkinson’s disease
Abstract Parkinson’s disease (PD) is characterized by a loss of dopaminergic neurons and accumulation of α-synuclein (α-syn)-containing Lewy bodies in the substantia nigra (SN) pars compacta. Mutations in the gene coding for the protein parkin cause a form of autosomal recessive juvenile parkinsonis...
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| Principais autores: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Portfolio
2026-05-01
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| Series: | npj Parkinson's Disease |
| Acceso en liña: | https://doi.org/10.1038/s41531-026-01371-2 |
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