Laboratory-Scale Lentiviral Vector Production and Purification for Enhanced Ex Vivo and In Vivo Genetic Engineering

Lentiviral vectors (LVs) are increasingly employed in gene and cell therapy. Standard laboratory production of LVs is not easily scalable, and research-grade LVs often contain contaminants that can interfere with downstream applications. Moreover, purified LV production pipelines have been developed...

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Principais autores:	Monica Soldi, Lucia Sergi Sergi, Giulia Unali, Thomas Kerzel, Ivan Cuccovillo, Paola Capasso, Andrea Annoni, Mauro Biffi, Paola Maria Vittoria Rancoita, Alessio Cantore, Angelo Lombardo, Luigi Naldini, Mario Leonardo Squadrito, Anna Kajaste-Rudnitski
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2020-12-01
Series:	Molecular Therapy: Methods & Clinical Development
Assuntos:	Lentiviral vectors purification process manufacturing gene therapy ex vivo in vivo
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2329050120302138
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