Inhibition of CXXC5 function rescues Alzheimer’s disease phenotypes by restoring Wnt/β-catenin signaling pathway

Alzheimer’s disease (AD) is the most prevalent type of dementia and is characterized by cognitive deficits and accumulation of pathological plaques. Owing to the complexity of AD development, paradigms for AD research and drug discovery have shifted to target factors that mediate multiple pathogenes...

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Principais autores:	Minguen Yoon, Heejene Kim, Heewon Shin, HeeYang Lee, Min-Jeong Kang, Sung-Hye Park, Gyoonhee Han, YoungSoo Kim, Kang-Yell Choi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-08-01
coleção:	Pharmacological Research
Assuntos:	Alzheimer’s disease 5xFAD Wnt/β-catenin signaling pathway CXXC5 Cxxc5-/-/5xFAD mice CXXC5-Dvl protein-protein interaction
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S1043661823001925
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