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CTCF/cohesin-binding sites are susceptible to replication-associated DNA damage and genomic instability in cancer cells

Summary: CTCF/cohesin-binding sites (CBSs) at the chromatin-loop anchors and topologically associating domains are frequently mutated in cancer; however, the underlying molecular mechanisms remain unclear. Here, we investigate whether CTCF and cohesin co-binding on DNA imposes constraints on DNA rep...

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Hoofdauteurs: Elangoli Ebrahimkutty Faseela, Dimple Notani, Radhakrishnan Sabarinathan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2026-02-01
Reeks:iScience
Onderwerpen:
Cell biology
Bioinformatics
Cancer
Online toegang:http://www.sciencedirect.com/science/article/pii/S2589004226000210
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