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Endothelial NLRP3 inflammasome activation and arterial neointima formation associated with acid sphingomyelinase during hypercholesterolemia

The NLRP3 inflammasome has been reported to be activated by atherogenic factors, whereby endothelial injury and consequent atherosclerotic lesions are triggered in the arterial wall. However, the mechanisms activating and regulating NLRP3 inflammasomes remain poorly understood. The present study tes...

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Autori principali: Saisudha Koka, Min Xia, Yang Chen, Owais M. Bhat, Xinxu Yuan, Krishna M. Boini, Pin-Lan Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2017-10-01
Serie:Redox Biology
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Accesso online:http://www.sciencedirect.com/science/article/pii/S2213231717303610
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