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Chromatographic profiling of leniolisib impurities using HPLC and LC-MS/MS: degradation behaviour, structural characterization, and in-silico toxicity evaluation

Background: This study presents a comprehensive analytical investigation of leniolisib, focusing on impurity profiling, degradation kinetics, structural characterization, and in silico toxicity prediction of degradation products (DPs). Methodology: A systematic approach was employed to optimize the...

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Principais autores: Rahul Gunupati, S. Lakshmi Tulasi, Rasheed Babu Shaik, L. Bhagya Lakshmi, Venkata Swamy Tangeti
Format: Artigo
Sprog:Inglês
Udgivet: Creative Pharma Assent 2025-08-01
Serier:Journal of Applied Pharmaceutical Research
Fag:
leniolisib
impurities analysis
stress degradation compounds
lc–ms/ms characterization
in-silico study
Online adgang:https://japtronline.com/index.php/joapr/article/view/1143
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