Chromatographic profiling of leniolisib impurities using HPLC and LC-MS/MS: degradation behaviour, structural characterization, and in-silico toxicity evaluation

Background: This study presents a comprehensive analytical investigation of leniolisib, focusing on impurity profiling, degradation kinetics, structural characterization, and in silico toxicity prediction of degradation products (DPs). Methodology: A systematic approach was employed to optimize the...

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Autori principali:	Rahul Gunupati, S. Lakshmi Tulasi, Rasheed Babu Shaik, L. Bhagya Lakshmi, Venkata Swamy Tangeti
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Creative Pharma Assent 2025-08-01
Serie:	Journal of Applied Pharmaceutical Research
Soggetti:	leniolisib impurities analysis stress degradation compounds lc–ms/ms characterization in-silico study
Accesso online:	https://japtronline.com/index.php/joapr/article/view/1143
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