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An mRNA mix redirects dendritic cells towards an antiviral program, inducing anticancer cytotoxic stem cell and central memory CD8+ T cells

Dendritic cell (DC)-maturation stimuli determine the potency of these antigen-presenting cells and, therefore, the quality of the T-cell response. Here we describe that the maturation of DCs via TriMix mRNA, encoding CD40 ligand, a constitutively active variant of toll-like receptor 4 and the co-sti...

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Main Authors: Wout de Mey, Hanne Locy, Kirsten De Ridder, Phaedra De Schrijver, Dorien Autaers, Asma Lakdimi, Arthur Esprit, Lorenzo Franceschini, Kris Thielemans, Magali Verdonck, Karine Breckpot
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
cancer
CD40 ligand
dendritic cell
interferon-gamma
interleukin-10
interleukin-12
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1111523/full
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