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Switching of hypertrophic signalling towards enhanced cardiomyocyte identity and maturity by a GATA4-targeted compound

Abstract Background The prevalence of heart failure is constantly increasing, and the prognosis of patients remains poor. New treatment strategies to preserve cardiac function and limit cardiac hypertrophy are therefore urgently needed. Human induced pluripotent stem cell-derived cardiomyocytes (hiP...

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Principais autores: Lotta Pohjolainen, Sini M. Kinnunen, Samuli Auno, Alexandros Kiriazis, Saana Pohjavaara, Julia Kari-Koskinen, Matej Zore, Mikael Jumppanen, Jari Yli-Kauhaluoma, Virpi Talman, Heikki Ruskoaho, Mika J. Välimäki
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-01-01
Serier:Stem Cell Research & Therapy
Fag:
Cardiomyocytes
Maturation
Hypertrophy
GATA4
Isoxazole derivatives
Online adgang:https://doi.org/10.1186/s13287-023-03623-x
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