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UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity.

The uncoupling protein 1 (UCP1) is a hallmark of brown adipocytes and pivotal for cold- and diet-induced thermogenesis.Here we report that cyclooxygenase (COX) activity and prostaglandin E(2) (PGE(2)) are crucially involved in induction of UCP1 expression in inguinal white adipocytes, but not in cla...

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Principais autores: Lise Madsen, Lone M Pedersen, Haldis Haukaas Lillefosse, Even Fjaere, Ingeborg Bronstad, Qin Hao, Rasmus K Petersen, Philip Hallenborg, Tao Ma, Rita De Matteis, Pedro Araujo, Josep Mercader, M Luisa Bonet, Jacob B Hansen, Barbara Cannon, Jan Nedergaard, Jun Wang, Saverio Cinti, Peter Voshol, Stein Ove Døskeland, Karsten Kristiansen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2010-06-01
coleção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC2894971?pdf=render
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