Carboxy-terminal mutations of bile acid CoA:N-acyltransferase alter activity and substrate specificity

Bile acid CoA:amino acid N-acyltransferase (BAAT) is the terminal enzyme in the synthesis of bile salts from cholesterol and catalyzes the conjugation of taurine or glycine to bile acid CoA thioesters to form bile acid N-acylamidates. BAAT has a dual localization to the cytosol and peroxisomes, poss...

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Autors principals:	Nathan A. Styles, Erin M. Shonsey, Josie L. Falany, Amber L. Guidry, Stephen Barnes, Charles N. Falany
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2016-07-01
Col·lecció:	Journal of Lipid Research
Matèries:	bile acid conjugation bile acid amidation taurine glycine N-acyltransferase bile acid ligase
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S0022227520351518
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