A parameterized two-domain thermodynamic model explains diverse mutational effects on protein allostery
New experimental findings continue to challenge our understanding of protein allostery. Recent deep mutational scanning study showed that allosteric hotspots in the tetracycline repressor (TetR) and its homologous transcriptional factors are broadly distributed rather than spanning well-defined stru...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications Ltd
2024-06-01
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| coleção: | eLife |
| Assuntos: | |
| Acesso em linha: | https://elifesciences.org/articles/92262 |
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