Anthracyclines disaggregate and restore mutant p63 function: a potential therapeutic approach for AEC syndrome
Abstract Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate (AEC) syndrome is a rare genetic disorder caused by mutations in the TP63 gene, which encodes a transcription factor essential for epidermal gene expression. A key feature of AEC syndrome is chronic skin erosion, for which no effective tre...
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| Hoofdauteurs: | , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group
2025-01-01
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| Reeks: | Cell Death Discovery |
| Online toegang: | https://doi.org/10.1038/s41420-025-02307-0 |
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