<em>Nkx2-5</em> Loss of Function in the His-Purkinje System Hampers Its Maturation and Leads to Mechanical Dysfunction

The ventricular conduction or His-Purkinje system (VCS) mediates the rapid propagation and precise delivery of electrical activity essential for the synchronization of heartbeats. Mutations in the transcription factor <i>Nkx2-5</i> have been implicated in a high prevalence of developing ventricular...

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Detalhes bibliográficos

Principais autores:	Caroline Choquet, Pierre Sicard, Juliette Vahdat, Thi Hong Minh Nguyen, Frank Kober, Isabelle Varlet, Monique Bernard, Sylvain Richard, Robert G. Kelly, Nathalie Lalevée, Lucile Miquerol
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2023-04-01
coleção:	Journal of Cardiovascular Development and Disease
Assuntos:	His-Purkinje system fast conduction markers RSR’ complex <i>Cx40</i> cell dropout strain defects
Acesso em linha:	https://www.mdpi.com/2308-3425/10/5/194
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