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Late-stage dedifferentiation and epigenetic memory of cancer stem cells in hepatocellular carcinoma

Abstract Background Cancer stem cells (CSCs) drive recurrence and drug resistance in hepatocellular carcinoma (HCC), but their origin remains controversial: are they tumour-initiating cells or late-stage dedifferentiation products? Direct human single-cell evidence linking bipotent progenitors (BPs)...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Yi-Kai Hu, Kun-Jiang Tan, Na Feng, Jing Li, Lu Chen, Yu-Xuan Lin, Hong-Yang Wang, Yu-Fei He
Hōputu: Artigo
Reo:Inglês
I whakaputaina: BMC 2026-06-01
Rangatū:Journal of Translational Medicine
Ngā marau:
Urunga tuihono:https://doi.org/10.1186/s12967-026-08494-3
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