Small molecule drugs promote repopulation of transplanted hepatocytes by stimulating cell dedifferentiation

Background & Aims: Hepatocyte transplantation has emerged as a possible treatment option for end-stage liver disease. However, an important obstacle to therapeutic success is the low level of engraftment and proliferation of transplanted hepatocytes, which do not survive long enough to exert the...

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Hlavní autoři:	Mengmeng Jiang, Ren Guo, Yan Ai, Gang Wang, Peilan Tang, Xiaohui Jia, Bingqing He, Qianting Yuan, Xin Xie
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2023-04-01
Edice:	JHEP Reports
Témata:	Hepatocyte transplantation Hepatocyte expansion Dedifferentiation Hepatocyte progenitor cells Small molecule compounds
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2589555923000010
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