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Opioid Facilitation of β-Adrenergic Blockade: A New Pharmacological Condition?

Recently, propranolol was suggested to prevent hyperlactatemia in a child with hypovolemic shock through β-adrenergic blockade. Though it is a known inhibitor of glycolysis, propranolol, outside this observation, has never been reported to fully protect against lactate overproduction. On the other h...

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Principais autores: Joseph Vamecq, Karine Mention-Mulliez, Francis Leclerc, Dries Dobbelaere
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2015-09-01
Serier:Pharmaceuticals
Fag:
lactate
glycolysis disruption
Na+/K+ ATPase
β-adrenergic receptor
G protein
cAMP
protein kinase A
shock
δ-opioid receptor
Online adgang:http://www.mdpi.com/1424-8247/8/4/664
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