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Effects of canagliflozin on myocardial microvascular density, oxidative stress, and proteomic profile

Introduction: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are cardioprotective, and canagliflozin (CANA), an SGLT2i, has been shown to improve perfusion, AMPK signaling, and oxidative stress in chronically ischemic myocardium. The aim of this study is to determine the effects of CANA in nonis...

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Autori principali: Sharif A. Sabe, Cynthia M. Xu, Mohamed Sabra, Dwight D. Harris, Mark Broadwin, Krishna G. Bellam, Debolina Banerjee, Anny Usheva, M. Ruhul Abid, Frank W. Sellke
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2023-12-01
Serie:Journal of Molecular and Cellular Cardiology Plus
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Accesso online:http://www.sciencedirect.com/science/article/pii/S2772976123000223
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