Relationships between genome-wide R-loop distribution and classes of recurrent DNA breaks in neural stem/progenitor cells

Abstract Recent studies revealed classes of recurrent DNA double-strand breaks (DSBs) in neural stem/progenitor cells, including transcription-associated, promoter-proximal breaks and recurrent DSB clusters in late-replicating, long neural genes that may give rise to somatic brain mosaicism. The mec...

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Hauptverfasser:	Supawat Thongthip, Annika Carlson, Magdalena P. Crossley, Bjoern Schwer
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2022-08-01
Schriftenreihe:	Scientific Reports
Online-Zugang:	https://doi.org/10.1038/s41598-022-17452-0
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