Increased Levels of cAMP by the Calcium-Dependent Activation of Soluble Adenylyl Cyclase in Parkin-Mutant Fibroblasts

Almost half of autosomal recessive early-onset parkinsonism has been associated with mutations in PARK2, coding for parkin, which plays an important role in mitochondria function and calcium homeostasis. Cyclic adenosine monophosphate (cAMP) is a major second messenger regulating mitochondrial metab...

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Detalhes bibliográficos

Principais autores:	Paola Tanzarella, Anna Ferretta, Simona Nicol Barile, Mariella Ancona, Domenico De Rasmo, Anna Signorile, Sergio Papa, Nazzareno Capitanio, Consiglia Pacelli, Tiziana Cocco
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2019-03-01
coleção:	Cells
Assuntos:	parkin mitochondria cAMP calcium
Acesso em linha:	http://www.mdpi.com/2073-4409/8/3/250
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