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Targeting of lysosomal-bound protein mEAK-7 for cancer therapy

mEAK-7 (mammalian EAK-7 or MTOR-associated protein, eak-7 homolog), is an evolutionarily conserved lysosomal membrane protein that is highly expressed in several cancer cells. Multiple recent studies have identified mEAK-7 as a positive activator of mTOR (mammalian/mechanistic target of rapamycin) s...

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Principais autores: Insoon Chang, Yi-Ling Loo, Jay Patel, Joe Truong Nguyen, Jin Koo Kim, Paul H. Krebsbach
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-03-01
Serier:Frontiers in Oncology
Fag:
mEAK-7
V-ATPase
lysosomal membrane protein
mTOR signaling
cancer
Online adgang:https://www.frontiersin.org/articles/10.3389/fonc.2024.1375498/full
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