Design and Engineering of Light‐Induced Base Editors Facilitating Genome Editing with Enhanced Fidelity

Abstract Base editors, which enable targeted locus nucleotide conversion in genomic DNA without double‐stranded breaks, have been engineered as powerful tools for biotechnological and clinical applications. However, the application of base editors is limited by their off‐target effects. Continuously...

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Detalhes bibliográficos

Principais autores:	Yangning Sun, Qi Chen, Yanbing Cheng, Xi Wang, Zixin Deng, Fuling Zhou, Yuhui Sun
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2024-02-01
coleção:	Advanced Science
Assuntos:	base editor low off‐target effect optogenetics spatiotemporal control
Acesso em linha:	https://doi.org/10.1002/advs.202305311
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