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An attenuated quadruple gene mutant of Mycobacterium tuberculosis imparts protection against tuberculosis in guinea pigs

Previously we had developed a triple gene mutant of Mycobacterium tuberculosis (MtbΔmms) harboring disruption in three genes, namely mptpA, mptpB and sapM. Though vaccination with MtbΔmms strain induced protection in the lungs of guinea pigs, the mutant strain failed to control the hematogenous spre...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Ritika Kar Bahal, Shubhita Mathur, Priyanka Chauhan, Anil K. Tyagi
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists 2018-01-01
Schriftenreihe:Biology Open
Schlagworte:
Multi-gene mutant
BCG
Tuberculosis
Attenuation
Auxotrophic vaccines
Biotin
Online-Zugang:http://bio.biologists.org/content/7/1/bio029546
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