Nanoparticles With Affinity for α-Synuclein Sequester α-Synuclein to Form Toxic Aggregates in Neurons With Endolysosomal Impairment
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. It is characterized pathologically by the aggregation of α-synuclein (αS) in the form of Lewy bodies and Lewy neurites. A major challenge in PD therapy is poor efficiency of drug delivery to the brain due to the blood–bra...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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Frontiers Media S.A.
2021-10-01
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| Schriftenreihe: | Frontiers in Molecular Neuroscience |
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| Online-Zugang: | https://www.frontiersin.org/articles/10.3389/fnmol.2021.738535/full |
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