Limitations of homologous recombination status testing and poly (ADP-ribose) polymerase inhibitor treatment in the current management of ovarian cancer

Homologous recombination (HR) is a highly conserved DNA repair system, in which aberrations can lead to the accumulation of DNA damage and genomic scars known as homologous recombination deficiency (HRD). The identification of mutations in key genes (i.e., BRCA1, and BRCA2 (BRCA)) and the quantifica...

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Principais autores:	Qianying Zhao, Liping Bai, Yu Tan, Mingrong Qie
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2024-07-01
Colecção:	Frontiers in Oncology
Assuntos:	homologous recombination (HR) PARP inhibitor (PARPi) ovarian cancer (OC) future prospect limitations
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1435029/full
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